The hand-foot syndrome was originally described in 1984 by Lokich and Moore. These three distinct and characteristic cutaneous reactions represent dose-limiting toxicities for these drugs and have a particular pathophysiologic mechanism that although largely unknown is probably not mediated by the immune system and has specific clinical characteristics, which are important from an oncologic perspective. The all-inclusive nature of the report would provide for a more effective presentation were it to focus on the three most common cutaneous reactions to chemotherapy: (1) hand-foot syndrome associated with the fluoropyrimidines (2) taxane-associated acral erythema with onycholysis and (3) the acneiform rash associated with the anti–epidermal growth factor receptor (EGFR) biologic agents. This article attempts to list the panoply of cutaneous manifestations or reactions that may be seen in cancer patients either as an epiphenomenon related to a cancer diagnosis or as a consequence of cancer treatment, particularly chemotherapy. This review provides a basis for the understanding of dermatologic events in the oncology setting, in order to promote attentive care to cutaneous health in cancer patients and survivors. Notwithstanding the critical importance of treatment-related toxicities, dermatologic conditions may also precede, coincide, or follow the diagnosis of cancer. Optimal care dictates that dermatologic toxicities must be addressed in a timely and effective fashion, in order to minimize associated physical and psychosocial discomfort, and to ensure consistent antineoplastic therapy. Most notably, cutaneous toxicities have gained considerable attention, due to their high frequency and visibility, the relative effectiveness of anti–skin toxicity interventions, and the otherwise decreasing incidence of systemic or hematopoietic adverse events. Whereas these novel medical, surgical, and radiation regimens, or combinations thereof, are largely responsible for these remarkable achievements, a new, unexpected constellation of side effects has emerged. You may report side effects to FDA at 1-80.The increased approval of anticancer agents has led to unprecedented results, with improved quality of life and longer survival times, resulting in millions of individuals living with a diagnosis of cancer. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur.
a metallic taste in your mouth (after clindamycin injection).severe stomach pain, diarrhea that is watery or bloody.liver problems-loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).kidney problems-swelling, urinating less, feeling tired or short of breath.Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body.
signs of an allergic reaction or a severe skin reaction
Get emergency medical help if you have (hives, difficult breathing, swelling in your face or throat) (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Side Effects What are the side effects of Clindamycin (Cleocin Hcl)?
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